Prof. Alice Roberts investigates the cause of death of Britain’s most famous monarchs. At the heart of each investigation is a detailed reconstructed autopsy led by Forensic Pathologist Dr Brett Lockyer. Together they search for any clues on the monarch’s body surface, then cut it open to study their internal organs. Alice takes her findings to leading medical and historical experts for further detailed analysis, exploring the cause and symptoms of any diseases, and how each ailment would have affected the regent, both in life and eventual death. Using eyewitness accounts sourced from the time of their deaths, the final dying days are also brought to life in vivid detail with exquisite scripted dramatic scenes. Ultimately, and based on the evidence, Prof Alice Roberts and Dr Brett Lockyer deliver their findings to reveal what they believe really did kill Britain's most famous royals.